Agenda

Monday, June 2, 2014
8:30 am - 4:30 pm
Conference Registration Open - ALL DAY
8:30 am - 12:00 pm
Strategic Management For Laboratories (AM)
1:00 pm - 4:30 pm
CALA Presents: Making The Most Of Accreditation (PM)
8:30 am - 4:30 pm
WCWC Course: Water Quality Sampling And Monitoring (Full-Day)
4:30 pm - 6:30 pm
Opening Reception & Keynote: Bob McDonald
Tuesday, June 3, 2014
7:30 am - 8:30 am
Registration & Continental Breakfast (Trade Show Area)
8:30 am - 8:45 am
Welcome To CALA C3

Charlie Brimley
President and CEO
CALA Inc.

8:45 am - 9:30 am
Laboratory Accreditation: Future Challenges

The International Laboratory Accreditation Cooperation (ILAC) has established worldwide recognition of laboratory accreditation bodies through periodic peer evaluations resulting in mutual recognition (aka the ILAC Arrangement). This international, multilateral mutual recognition agreement among accreditation bodies aims to develop a global network of accredited testing, calibration and inspection facilities that can be relied on to provide impartial and accurate data. The fundamental purpose is to provide confidence in the competence of bodies supporting these activities. The speech will highlight the role of ILAC, the challenges facing the present system, the need to update the ISO/IEC 17000 series standards, and the long-standing issues of adequate measurement traceability and the application of measurement uncertainty.

Peter Unger
Chair
International Laboratory Accreditation Cooperation (ILAC)

Peter Unger is President & CEO of the American Association for Laboratory Accreditation (A2LA). A2LA is a nonprofit, membership organization administering the largest, internationally recognized laboratory accreditation system in the United States and one of the leading bodies in the world with over 2,300 accreditations.

Mr. Unger has been involved with national laboratory accreditation since 1978. Prior to attaining his current position in April 1996, Mr. Unger served as Vice President of the Association and prior to that, was Associate Manager of Laboratory Accreditation at the National Bureau of Standards.Mr. Unger serves as Chair of the International Laboratory Accreditation Cooperation (ILAC) for 2012-2014. Mr. Unger has a BS degree in systems engineering from Princeton University and a masters in environmental management from George Washington University.

9:30 am - 10:30 am
Measurement Of 226Ra By ICP-MS (Technologies Stream)

226Ra is an important analyte in drinking water and effluents from mining operations due to its radioactivity and long halflife. 226Ra in mine effluents is regulated under metal mining and effluent regulations in Canada. Standard radiometric methods for the analysis of 226Ra are based on alpha spectroscopy after separation and concentration of the analyte via precipitation and filtration. A novel method employing online preconcentration and analysis via ICP-MS for the measurement of 226Ra in effluents is presented. The method has been successfully implemented at an operating mine site for the analysis of effluent water quality on a daily basis.

Angelo Fernando
Chief Scientist, Analytical Chemistry
Cameco Corporation

Angelo Fernando holds the position of Chief Scientist, Analytical Chemistry at Cameco Corporation, a leading uranium producer of the world. He has supervised laboratories at uranium mining operations for more than ten years and is a volunteer lead assessor for CALA. Angelo, completed his graduate studies in Analytical Chemistry at the University of Alberta, Edmonton, Alberta.


Lessons Learned From The 2012 Quebec City Legionellosis Outbreak: New Provincial Regulation For Cooling Towers Maintenance and Legionella Monitoring (Regulatory Stream)

Québec City's population experienced a major outbreak of legionellosis during the summer of 2012, with 181 cases and 13 deaths. The Legionella source was an air conditioning cooling tower in the center of the city. At the time, no regulation required owners of cooling towers to manage Legionella levels in water and its associated health risks. Last spring, the Québec provincial government implemented a regulation requiring cooling tower owners to have a maintenance plan. The Québec government also assessed requiring monthly Legionella monitoring in 2014.

This presentation will look back on the 2012 outbreak and explain the actions taken by the Québec government to implement its new regulation. Legionella analysis and laboratory accreditation for Legionella analysis will also be discussed.

Key Points

  • Québec City legionellosis outbreak
  • Québec province Legionella regulation for cooling towers
  • Legionella analysis
  • Legionella laboratory accreditation

 

Philippe Cantin
Head Microbiologist
Microbiology Laboratory
Ministère du Développement


What's Your poison? How Certified Reference Materials (CRMs) Protect Public Health (Quality Management Stream)

Many laboratories around the world perform routine testing on a wide range of samples such as food, water or biological materials. The results may have important public health implications as well as strong economic impact. For these reasons, the implementation of quality systems based on international standards is necessary. These standards provide procedures for the implementation of external and internal quality control for all activities conducted in the laboratory verification of the quality of results and periodic verification of the quality control system. One of the most important tools for quality control is the use of reference materials. A reference material is a substance or material in which one or more of its properties have a value sufficiently homogenous and well established to be used for the calibration of an apparatus, the evaluation of a measurement, or the validation of analytical methods. The NRC Certified Reference Materials (CRMs) program, which is operated by the Measurement Science and Standards portfolio, provides CRMs for analysis of biotoxins and other organic and inorganic contaminants in environmental samples, food and nutritional supplements. Over the years this program has developed in scope and today NRC is internationally recognized as an important producer of CRMs, which are distributed to over 40 countries.

Ruth Perez Calderon
Technical Officer Scientist
National Research Council of Canada

Ruth Perez Calderon is currently a Technical officer scientist and Quality Scope Coordinator at National Research Council of Canada in Halifax, Nova Scotia. Since joining in 2006, her research efforts have focused on the production of CRMs, developing of methods, method validation and implementation of the Biotoxin Metrology quality system. She also, is currently a volunteer CALA assessor.

She previously held a research position in the National Health Institute in Peru and participated as a technical expert in testing laboratory accreditation assessments with the Peruvian accreditation body. In this role she worked on the development and validation of new mythologies for analysis of contaminants in food, environmental and biological samples. She received her Chemical engineering bachelor degree in 1991 and her Master degree in 2007 from University Federico Villarreal in Lima, Peru.

She has published some papers and is the recipient of awards including the Outstanding Research award for the production of CRMs in 2006 within NRC and the Prize for the Best Panel at the Latin-American Chromatography conference in 2002.

In her spare time, Ruth can be found teaching dancing, fitness or enjoying good food.

10:30 am - 11:00 am
Networking & Refreshment Break (Trade Show Area)
11:00 am - 12:00 pm
Why The Analysis Of Persistent Organic Pollutants Is Like Finding A Needle In A Haystack (Technologies Stream)

Pinpointing persistent organic pollutants (POPs) among the ~100,000 chemicals used in industry and commerce represents major analytical and logistical challenges. As a consequence of their chemically inert behaviour, POPs are often toxic, resistant to degradation and prone to accumulate in living organisms.

Mass spectrometry (MS), typically hyphenated with (gas or liquid) chromatography, has developed into the most widely used technique for the analysis of POPs. Nowadays, it is relatively straightforward to develop highly sensitive and selective MS based methods for the identification and quantification of suspected POPs. However, such targeted methods are not usually helpful for the analysis of unknown POPs.

Sifting through the enormous data sets generated by current- and next-generation instrumentation is a major obstacle to identifying unknown POPs. One way to overcome this is to classify potential POPs on the basis of their mass defect, i.e., the slight deviation of the exact mass of a molecule from its integer value. It will be shown that an integrated strategy involving sophisticated MS technology, automated data processing software and in vivo toxicology experiments provides an efficient means to identify environmental pollutants in a variety of complex environmental samples.

Highlights: 

  • Participants will learn about mass spectrometry based techniques for the identification of unknown toxic organic compounds.
  • Key challenges include the interpretation of the large data sets generated by modern instruments.
  • These challenges can be addressed by software automation.

Karl Jobst
Development Scientist
Ontario Ministry of the Environment

Karl Jobst is a graduate of McMaster University, in Hamilton, Ontario, where he received both his B.Sc. and Ph.D. degrees in chemistry.

His thesis focused on the study of catalysis in the chemistry of gas-phase organic ions using mass spectrometry experiments and theoretical calculations. Some of this research was relevant to the chemistry of interstellar space, but following graduation, Karl pursued more Earth-oriented studies as a Postdoctoral Fellow at Environment Canada. In 2013, he joined the Laboratory Services Branch of the Ontario Ministry of the Environment.

Karl is currently interested in the development and application of sophisticated mass spectrometry and (multidimensional) chromatography techniques capable of tackling challenging environmental analytical problems.


Integrating The Quality Function Into Lab Strategy Through Innovative Business Models (Technologies Stream)

Laboratories meeting ISO 17025 and other quality standards and Codes have statements describing their quality objectives and quality policies. These statements often fall short in linking quality to Laboratory competitive strategy. A reason for this short fall is that laboratories, in general, tend to view quality as a stand alone function. Laboratories interested in sustained competitive advantage must link their quality function to the overall business performance of the laboratory. This presentation will discuss:

  1. Definition of Quality as it relates to laboratory operations and business strategy.
  2. The advantages and disadvantages of viewing quality as a standalone function.
  3. The rationale for linking quality to laboratory strategy.
  4. A proposal for integrating quality into laboratory strategy by Implementing an Innovative Business Model.

Adam Habayeb
Founder
Strategy First Consulting SFC

Dr. Habayeb is the Founder of a Management Strategy Firm called "Strategy First Consulting". He spent over 20 years working in the quality,technology development and management and Performance Assurance areas. He was a Quality Assurance Coordinator for a large integrated laboratory that conducted and developed test methods in Radio chemical, Inorganic and Organic analyses. To date, he has participated in over 15 CALA based assessments. In addition, he has completed a large number internal and external audits in the areas of ground water systems, safeguards and emergency planning and response programs. He also supervised qualified auditors and audit team leaders. He has also been involved in conducting Effectiveness Reviews of Various Assurance Programs to determine their effectiveness in meeting Corporate needs.

He has completed studies including Evaluation of Funding Options of R&D and Engineering laboratories, Mergers & Acquisitions and Spinning Off of knowledge-based organizations.

Dr Habayeb has a Ph.D in Chemistry from McMaster University and an MBA from SUNY-Buffalo,NY and an Advanced Certificate in Managing Strategic Change from Rotman School of Management-University of Toronto


From Scratching To Tapping...Using A Tablet To Replace Audit Checklists (Quality Management Stream)

This session will help participants with :

  • Better facilitation of internal and external auditing
  • Unexpected benefits for the audit team and lab staff
  • Improved accuracy and efficiency in preparation for audits and record maintenance

Terri Molloy
Staff Technologist
QMP-LS

Terri is a Certified Quality Auditor (ASQ) and Medical Laboratory Technologist (MLT) currently working as a coordinator of audits for the Ontario Laboratory Accreditation program a division of Quality Management Program – Laboratory Services.
Terri has recently had the opportunity to expand her role as coordinator into the provinces of Newfoundland and Labrador as well as New Brunswick. This role has given her the opportunity to manage and actively assess more than 100 laboratories against the ISO 15189 standards for Medical Laboratories. Terri has given educational lectures at the LabQuality Confab in San Antonio, Texas and the Point of Care symposium in Toronto, Ontario.
She is a graduate of The Michener Institute and a member of the College of Medical Laboratory Technologists of Ontario. Prior to working at QMP-LS, Terri spent 20 years working at Sunnybrook and Women’s Health Sciences Centre, Toronto in the Hematology and Transfusion Medicine laboratories.

12:00 pm - 1:00 pm
Lunch & CALA Awards Presentations
1:00 pm - 1:55 pm
CAPE Study For The Analysis Of Dioxin And Dioxin Like Compounds (Technologies Stream)

The analysis of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzo-furans (PCDFs) and dioxin-like polychlorinated biphenyls (dlPCBs), as well as other persistent organic pollutants (POPs) such as polybrominated diphenylethers (PBDEs) and polychlorinated naphthalenes (PCNs) is very challenging. Prior to instrumental analysis, all desired components of a compound group must be extracted from sample matrix. Target compounds must then be separated and purified by removing interferences through a cleanup procedure. Traditional open column cleanup for POPs takes up to three days for a set of ten samples for each of these groups of compounds excluding the time required for glassware cleaning and background contamination checks. Many laboratories analyse the various POPs separately, or combine two of the groups together due to difficulties in collecting the analytes in a single extract. In the past decade, automated extraction and cleanup systems have been adopted for the analysis of these compounds. Automated methods can produce reliable results for all four of the aforementioned groups of compounds, but requires extensive washing of the system between sample batches to minimize carryover and contamination. In this study, the CAPE Technologies cleanup technique was investigated for determination of dioxins and dioxin like compounds in environmental samples. Disposable columns provided by CAPE Technologies were used to analyze PCDD/Fs, dlPCBs, PBDEs and PCNs together in one analytical run for fish tissue and sediment samples. All four groups of compounds were successfully separated into two fractions. The results for compounds in each group were consistent and of high quality. Using disposable columns significantly reduces the cleanup time from three days to one day. Besides, using disposable columns eliminates cross contamination between sample batches. In addition, this technique uses much less solvent and generates much less waste solvent than other methods. The CAPE Technologies cleanup technique is simple, fast, inexpensive and environmentally friendly when compared to traditional and automated methods. It can be used as an effective cleanup method for the simultaneous sample preparation of PCDD/Fs, dlPCBs, PBDEs and PCNs for a variety of environmental matrices

Sheng Yang
Technologist
Ontario Ministry of the Environment

Sheng Yang is a Dioxin Compounds Technologist at the Laboratory Services Branch (LaSB), Ontario Ministry of the Environment (MOE). She received a B.Sc. degree in Biology from Shanghai Teachers University, P.R. China and graduated M.Sc. in Environmental Science from University of Toronto, Ontario. Her international experience includes practical analytical chemistry experience in several analytical laboratories in Singapore and China. Since then, she has been working on sample preparation for dioxin analysis at the Toxic Organic Section, LaSB, MOE for ten years. Sheng received the Performance Excellence Award in July 2013 at LaSB, MOE. Her current research involves study of adopting the CAPE Technologies cleanup technique to simplify the analysis of multi-analyte dioxin-like persistent organic pollutants.


Why ISO 17025 Accreditation Matters; Not Just To The Laboratory And Its Immediate Client - But To All Stakeholders (Regulatory Stream)

 

The ISO 17025 standard is an ISO standard that has been in place for about fifteen years and used in Canada and elsewhere, mostly in the developed and developing world to accredit laboratories. It has been adopted by many commercial and public laboratories since its inception in 1999. Interestingly, just before this ISO standard became common, but around the same time, a few serious water quality incidents occurred that help speak to the standards importance.


In July 1998, Sydney Australia with a population of just over 2 million suffered a very serious potable water crisis based on erroneous parasite data, resulting in a credibility crisis for its water utility. At the time of the incident, the utilities water quality laboratory in Sydney was very highly thought of, and was one of the few public laboratories undertaking research into Cryptospiridium and Giardia Lambdia detection and analysis. In 2000, a much smaller community in Eastern Canada, Walkerton, Ontario suffered a drinking water catastrophe resulting in a number of deaths. As a consequence, ISO 17025 accreditation received more support as a result of the follow up public inquiry. Although laboratory test, results weren't identified as a concern, how they were or were not communicated did become an eventually become an issue. In 2001 another incident, this one also involving Cryptospiridium resulted in an outbreak of cryptosporidosis in the City of North Battleford, Saskatchewan. Similar to the other two cases, it took a period of time to identify the source of contamination in this event.


In one situation, we have a small town in Southern Ontario dealing with an E.Coli:0157 outbreak, in the other we have a very large community, Sydney, Australia engaged in a supposed Cryptospiridium/Giardia outbreak that ultimately resulted in a boil advisory for a City of over 2 million people for a period of two weeks. In the one, a lack of knowledge about what the lack of chjorination and the E.Coli values actually meant had catastrophic consequences on the local community. In the other, the lack of standard laboratory test procedures for a modern sophisticated laboratory undertaking research on the a new and evolving test method for Cryptospiridium and Giardia Lamdia resulted in an unwarranted boil water advisory for that City. In the last example, we encounter a situation, that involved a lack of general education about the risks of discharging raw sewage, effectively just upstream of a water supply system intake.


Although these incidents share potable water quality contamination issues in common, they also represent segments of our developed society from the rural to the large metropolitan community. These incidents also point to the use of laboratories that were not ISO 17025 accredited. This paper then, aside from explaining the criticality of ISO 17025 for ensuring consistent and reliable laboratory analytical information and interpreting it correctly, will illustrate how laboratory data from unaccredited laboratories can differ significantly from ISO 17025 accredited laboratories. This will become increasingly important as analytical equipment, and by extension laboratories, have the ability to measure compounds in the parts per trillion and quadrillion range. How the various levels of government respond to the challenges associated with legislating these compounds, or finding a surrogate, and how will accreditation agencies such as CALA accredit laboratories that analyze for these compounds is an ongoing issue that has now been underway from some time.

 

 

 

 

Klas Ohman
Senior Enviornmental Engineer
Associated Engineering

Presently, Dr. Ohman is a Board Member with the Canadian Association for Laboratory Accreditation as well as the Chair of the Drinking Water Quality Committee for the Canadian Water and Wastewater Association. He was a member of the Associations Technical Paper Review Committee for the 2012 biennial Canadian Drinking Water Conference as well as the recent Environmental Specialty Conference for the Canadian Society of Civil Engineers in Edmonton.

He is currently a Senior Environmental Engineer with Associated Engineering in their Calgary office.


Biological Method Development: Why Not Keep Quality In Mind? (Quality Management)

From 2007 to 2010, in partnership with the University of Guelph, the development of an Ontario Ministry of the Environment laboratory method to assess bioaccumulation of contaminants from field-collected sediments in three freshwater organisms was undertaken. From the very beginning the method was developed with standardization in mind. After a very thorough literature review of current practice in bioaccumulation assessments, meticulous thought went into assessing the impact of key variables on data quality (e.g., loading density, organism size, standardizing sediment total organic carbon). In the end a Ph.D. thesis and "Bioaccumulation of sediment-associated contaminants in freshwater organisms" method were complete. Then came the task of putting this method into practice in a production laboratory for new sediments and new and emerging compounds. The authors will discuss how the process of accrediting and co-ordinating an inter-laboratory assessment of a new method has posed both interesting and frustrating challenges. Along the way the authors will attempt to draw parallel comparisons between chemical and biological method development and highlight the aspects of biological testing that make it unique. In addition, how the strong basis of method validation to the international standard, ISO 17025 has allowed this method to confidently be adapted to answer new and challenging questions will be discussed.

Trudy Watson-Leung
Sediment Toxicologist
Ontario Ministry of the Environment

2:05 pm - 3:00 pm
Qualitative And Quantitative Analysis Of Environmental Contaminants Of Emerging Concern - Development And Validation Of An UHPLC-Orbitrap MS (Technologies Stream)

Contaminants of emerging concern (CECs) in the environment are generally described as contaminants that were unknown, unrecognized (not detectable) or unregulated (not routinely monitored) and, represent a diverse group of chemicals that may pose a risk to human health and the environment. CECs can be discovered with either newly available analytical technologies and/or implicated by a prior knowledge of the process details. Due to limited analytical capability (e.g., hardware, software, analytical standards), analysis of CECs has been focused on selected analytes rather than a holistic approach, which includes as many known chemical classes in the analysis as possible. Using water and wastewater treatment plant samples, a new analytical workflow was proposed, applied and evaluated in the quantitative analysis of 58 CECs and qualitative analysis of their treatment by-products.

An ultrahigh performance liquid chromatography (UHPLC) system with Thermo Hypersil Gold® and Betasil® C18 columns, 2.6 , 2.1x100mm to separate acidic and base/neutral compounds was used. Analytes eluted from these two analytical columns were transferred via an electrospray ionization source (ESI) to an Orbitrap mass spectrometer (Orbitrap MS, ThermoFisher Scientific Exactive Plus), analyzed in positive and negative ionization modes at mass resolution setting of 140,000. The UHPLC separations used a flow rate of 0.45 mL/min and 15-min gradient elution. Mobile phases used for positive ionization were 5 mM HCOONH4/0.1% HCOOH in 10:90/CH3OH:H2O (A) and 90:10/CH3OH:H2O (B); and negative ionization used 10:90/CH3CN:H2O with pH adjusted to 6.95±0.3 (A) and CH3CN (B). These parameters and the column used produced chromatographic peaks with full-width-at-half maximum (FWHM) of about eight seconds. The Orbitrap MS was set to collect data from 95 to 950 amu at a scanning speed of about 1.7 scans/sec, resulting in 25-30 data points to precisely define chromatographic peaks. Analytical data were transferred to an offline data processor where data were screened against a database of >400 target compounds (CECs) including phthalates, anesthetics, biocides, corrosion inhibitors, musk fragrances, quaternary ammonium surfactants, sunscreen cosmetics, UV-light stabilizers, hormones, estrogens, veterinary drugs, pesticides, perfluorohydrocarbons, pharmaceuticals and personal care products (PPCPs) and known metabolites, and treatment byproducts of pesticides and PPCPs. Using TraceFinder 3.1 software, identification of these target compounds was performed by UHPLC retention time and accurate mass of quasi molecular ions (i.e., protonated molecule ion or ion formed from a molecular ion by loss of a hydrogen atom) of each target. Taking advantage of the long-term mass axis stability of the Orbitrap MS, a mass extraction window of ±5 ppm was used to do both qualitative and quantitative analysis. Quality control/quality assurance data obtained from routine UHPLC-Orbitrap MS analysis of clean water samples have shown good precision and accuracy for the 58 target compounds analyzed. Quantitative analysis was performed for target compounds with analytical standards while area counts of positively-identified analytes were used to monitor treatment efficiency, occurrence, temporal and seasonal trends. This method eliminates matrix effects observed in UHPLC/tandem mass analysis particular seen in the analysis of ethinylestradiol (EE2), allowing for the unambiguous identification and quantitation of EE2 and other estrogens in environmental samples.

Paul Yang
Senior Research Scientist
Ontario Ministry of the Environment

Dr. Paul Yang received his B.Sc. in physical chemistry from National ChungHsing University in Taiwan and his Ph.D. in analytical chemistry from Ohio University, Athens, OH, USA. His North-American work experience includes appointments at the department of chemistry, University of California, Riverside, CA; Molecular Spectroscopy Section of the National Research Council of Canada; and manager of the Applied Chromatography Section of Ontario Ministry of the Environment. He is currently holding an appointment as a Senior Research Scientist with the Laboratory Services Branch, Ontario Ministry of Environment. His expertise includes separation sciences, vibrational spectroscopy (IR), liquid chromatography (LC), gas chromatography (GC) and mass spectrometry (MS). He applies these technologies alone, or in hyphenated mode (i.e., GC-IR, GC-MS, GCxGC-TOF-MS, GC-TOF-MS, LC-MS/MS, LC-TOF-MS, and LC-Orbitrap MS) for the analysis of persistent and emerging organic pollutants including organochlorince, polychlorinated congeners, pesticides, pharmaceuticals and personal care products; as well as the application of chemoinformatic technologies to interpret and analyze large datasets. Dr. Yang authored/co-authored more than 80 scientific publications and is a founding Member of the Calibration Validation Group and a Member of the Integrated Atmospheric Deposition Network for long-range monitoring of cross-boundary transport of hazardous substances.


The Performance Of Accredited And Non-Accredited Laboratories In The CALA Proficiency Testing Program 2003-2013 (Quality Management Stream)

This presentation examines the aggregate performance of accredited and non-accredited laboratories in CALA proficiency testing studies, using summary data reported on the CALA web site (http://www.cala.ca/pt_accred_vs_nonaccred.html). Failure rates of the two groups are tracked for some individual test groups, and for multiple test groups combined, in 19 rounds between October 2003 and January 2013. The results demonstrate improved performances of both groups over the 10-year period, and that for several of the test groups there is at least a 99% level of confidence that the mean failure rate for non-accredited laboratories is greater than that for accredited laboratories.

Rick Wilson
Retired
CALA

Rick Wilson was Chief Executive of CALA from 1994 to 2008, and was sponsored by CALA while he was Chair of the Proficiency Testing Advisory Committee at the International Laboratory Accreditation Cooperation from 2008 to 2010. Prior to joining CALA he worked for the Government of British Columbia and taught at McGill University.

Ken Middlebrook
Proficiency Testing Manager
CALA

Ken is CALA's long-standing Proficiency Testing Manager and represents CALA on the Laboratory Committee at the International Laboratory Accreditation Cooperation.


Real Uncertainty In Analysis (Quality Management Stream)

Lab uncertainty is a quantifiable term related to the analytical method. However,it is a very misleading and almost insignificant term in the analysis of soils where 1-2 g sub-samples are being forced to represent the 100-200 g sample delivered to the lab. The problem is largely being ignored with the result that many soil analyses are statistically meaningless, especially when the soil is coarse-grained and the contaminant levels are low. The real uncertainty in these cases can be several hundred percent and this is creating great confusion for the consultant in the interpretation of the site condition, resulting in needless cleanups in some cases and needless failures to clean up in others. Real life examples will be presented and possible solutions discussed.

George Duncan
President
A & A Environmental Consultants Inc

3:00 pm - 3:30 pm
Networking & Refreshment Break (Trade Show Area)
3:30 pm - 4:15 pm
Plenary : Designing For Tomorrow - Lab Design Considerations For Chemical Laboratories.

Most of the Chemical laboratories designed to support manufacturing operations, are design/built on a conventional casework basis, by architects and engineers with little knowledge of advanced analytical methods and advancements in equipment technology. The presentation will focus on the different design aspects of a chemical lab, with emerging technologies in both lab peripherals and instrumentation. It will look at the modular design concepts and briefly touch on the footprint changes for analytical instruments like XRF, ICP, NMR and other analytical instruments.

Syed Rizvi
Manager of Technical Development
Suncor Energy

Syed Rizvi, has been engaged in the Oil/Gas/Chemical industry for over 25 years, currently working with Suncor as Manager technical developmen.In the past, he has been engaged in designing of Chemical labs for a number of companies that he have worked for, including, Texaco, Exxon, Gul Ahmed.

Wednesday, June 4, 2014
7:30 am - 8:30 am
Registration & Continental Breakfast (Trade Show Area)
8:30 am - 8:45 am
Welcome To Conference
8:45 am - 9:30 am
What Is On The Regulatory Horizon For The Laboratory Testing Community - A Panel

Representatives from the Canadian Food Inspection Agency (CFIA), a regional municipality, a representative speaking for provincial regulators as well as a member of the private sector have all been invited to each brief the delegates on what may be on the horizon from the various perspectives of the regulators.

Dr. Corinne Pequignot
Director Quality Assurance and Accreditation
Food Safety Science Directorate
Canadian Food Inspection Agency

Dr. Corinne Pequignot joined the Federal Government in 2002, where she held positions with increasing responsibility, first at Health Canada and later at the Canadian Food Inspection Agency. In 2006 she assumed the role of Director of the Ottawa Laboratory Carling, which is a food, feed and fertilizer laboratory doing routine testing and research in both biology and chemistry. For the last 2 years, she has been managing national files as the Director of Quality Management and Biosafety. Prior to joining the Federal Government, Dr. Pequignot worked in the academic and industrial sectors in France and in Canada doing research and development in areas related to industrial microbiology.

Dr. Corinne Pequignot is a native of France and a graduate of the Université Blaise Pascal in France, where she obtains a Ph.D. in Food Processing Engineering.

Dan Toner
Assistant Director, Laboratory Services Branch
Manager, Environmental Forensics Section
Ontario Ministry of the Environment

Dan Toner is the Assistant Director of the Laboratory Services Branch of the Ontario Ministry of the Environment and the Manager of the Environmental Forensics Section. Dan has been working with the MOE for 32 years. During that time he has managed organic and inorganic laboratories, served as Quality Manager and has been involved with environmental regulations from a laboratory perspective, including the Safe Drinking Water Act and regulations, the Nutrient Management Act and regulations and the Brownfield Regulation 153/04.

Barry Loescher
Quality Systems Specialist
Maxxam Analytics

Rosa Gonzalez
Manager
Compliance and Regulations, Public Works Department
City of Hamilton

Rosa Gonzalez is the Manager of Compliance and Regulations for the Hamilton Water Division. Rosa has twenty five years of experience in the area of water and wastewater testing, quality control, quality management and applicable environmental regulatory requirements. This experience includes managing staff responsible for providing environmental laboratory services, implementing and maintaining a water quality management system, overseeing environmental regulations, and sewer use by-law enforcement.

Rosa has a degree in Chemistry from the Universidad Técnica Santiago, Chile and a bachelor in Science from the University of Toronto.

Cammy Mack
Assistant Director, Safe Drinking Water Branch
Manager, Laboratory Licensing & Compliance Program
Ontario Ministry of the Environment

Cammy Mack is the Assistant Director of the Safe Drinking Water Brach of the Ontario Ministry of the Environment and the Manager of the Laboratory Licensing & Compliance Program. Cammy started her life-long career in the MOE Lab in 1985 and held various positions including that of a CALA Lead Auditor. After the Walkerton tragedy in 2000, she worked with Dan Toner to develop lab-related legislation and the Lab Licensing and Compliance program. In addition to drinking water system and lab compliance oversight, Cammy is currently leading the development of the Ministry’s risk-based municipal wastewater, municipal stormwater and reactive private well compliance programs. After receiving her BA in Law this September, her goal is to become an Ontario Justice of the Peace when she retires.

9:30 am - 10:30 am
Organic and inorganic contaminants in natural-matrix material: NCP III Phase 7 Assessment of Laboratory Performance.

Natural – matrix materials such as fish and mussels tissues were used in the NCP III Phase 7 interlaboratory study (ILS) which was conducted to assess the performance of laboratories providing data to Northern Contaminants Program (NCP) and to Arctic Monitoring and Assessment Programme (AMAP). This study is part of the NCP III Quality Assurance/Quality Control (QA/QC) Program. The QA/QC studies focused on performance evaluation of analytical laboratories providing data to the NCP managers. Analysis is performed on contaminants of concern such as trace metals, persistent organic pollutants (POPs) and emerging contaminants. The number of participating laboratories increased from the previous study (42 vs 32 labs) and has doubled since Phase 1 (19 labs in 2005/2006).

Six natural-matrix materials and twelve injection-ready standards were provided to assess levels of organic and inorganic contaminants. Data quality assessments were conducted for dioxins, organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs) and emerging contaminants (polybrominated diphenyl ethers (PBDEs) including brominated flame retardants (BFRs), perfluorinated chemicals (PFCs), polychlorinated naphthalenes (PCNs), chlorinated paraffins (CPs), and trace metals including mercury and methyl mercury. Results were evaluated using “Robust Statistics: a method of coping with outliers”. Compared to the previous rounds, laboratories demonstrated higher performance for certified natural-matrix material for PDBEs/BFRs, OCs, trace metals and higher performance for uncharacterized natural-matrix material for PCDDs/PCDFs/DLPCBs. The increased numbers of participated laboratories helps to expand the database and data comparability of the results. The final NCP III Phase 7 QA/QC report is available upon request. An eighth round in the series of studies is currently being conducted in anticipation of achieving further improvements in the analysis of these contaminants. An overview of the program and results of laboratory analytical performance will be disused.

Victoria Tkatcheva
NCP QA/QC Coordinator
Northern Contaminants Program
Ministry of Environment


Measurement Traceability and Calibration (Quality Management Stream)

Section 5.6 of ISO 17025 requires that all equipment used for tests and/or calibrations, including equipment for subsidiary measurements (e.g. for environmental conditions) having a significant effect on the accuracy or validity of the result of the test, calibration or sampling shall be calibrated before being put into service and that the programme for calibration of equipment shall be designed and operated so as to ensure that calibrations and measurements made by the laboratory are traceable to the International System of Units (SI). This presentation will review in detail the many aspects of this section of the standard; discuss various interpretations (such as - what is "a significant effect" and explore how they apply to testing labs using either external calibration providers or in-house calibration methods.

Georgette Macdonald
Program Leader
Scientific Support for the National Measurement System
National Research Council Canada

Ms. Macdonald has experience as a calibration technologist (mass), laboratory manager, quality manager, technical assessor, lead auditor, peer reviewer and trainer. She holds a civil engineering degree and an MBA. She is currently employed at the National Research Council Canada.


Quantitative Analysis Of The Accuracy Of The Uncertainty Of Measurement (Quality Management Stream)

Quantitative Analysis of the Accuracy of the Uncertainty of Measurement Mike Gao, Debra Long and Steve Craik (EPCOR Water Services, Edmonton, AB) Abstract Any measurement has its uncertainty. Uncertainty is considered to be an attribute associated with the measurement result. Uncertainty of measurement (UM) is defined as a parameter that characterizes the dispersion of the values that can reasonably be attributed to the measurand (BIPM, etc., Guide to the Expression of Uncertainty in Measurement, 2008). The estimation of UM is a requirement of ISO/IEC 17025 due to the limitation of the test method, the needs of the customers and the existence of narrow limits on which conformity to a specification are based. Therefore, the accuracy of the estimated uncertainty becomes important. In order to estimate the true value of the measurand, a limited number of repetitive measurements are performed and the mean result is calculated. The mean result is the best estimate of the true value. Similarly, the UM is calculated based on a limited number of repetitive measurements. Therefore, the estimated UM also has its own uncertainty for a defined number of repetitive measurements. The larger number of repetitive measurements used in the estimation, the closer the mean result is to its true value and the closer the estimated UM is to its true uncertainty. This study focuses on the quantitative analysis of the UM. The F-test is used to evaluate the accuracy (or inaccuracy) of the estimated UM and to define the confidence intervals of the UM. The correlation between the uncertainty of the UM and the number of repetitive measurements is also studied. A consideration of applying a safety factor in the reportable UM is discussed. Both the theory and the application are examined. The Monte Carlo technique is used in the simulation of the application. This study will provide meaningful guidance for users when UM, associated with the measurement result, is a significant consideration in decision making. It also helps people to better understand the statistical meaning of quality control limits and to set up scientifically sound quality control statistics that are fit for the purpose of measurement.

Mike Gao
QA System Specialist
EPCOR Water Services Inc.

* Ph.D in Analytical Chemistry
* P.Chem with the Association of the Chemical Profession of Alberta (ACPA)
* over twenty years of lab experience as lab scientist and QA Specialist in the fields of environmental analysis and geochemical analysis.
* CALA Assessor (ISO/IEC 17025 assessor) for 8 years
* Author of over thirty peer-reviewed publications

Debra Long
Senior Manager
Quality Assurance, EPCOR Water Services Inc.

* MSc in Public Health
* Over twenty years of lab experience in lab management and QA
* Senior Manager, Quality Assurance, EPCOR Water Services

10:30 am - 11:00 am
Networking & Refreshment Break (Trade Show Area)
11:00 am - 12:00 pm
A Guide To The Selection And Use Of Calibration Algorithms In Analytical Chemistry (Technologies Stream)

The majority of analytical methods using instrumental detection assume a simple linear y = mx + b type relationship between analyte concentration and either instrument response or a mathematical transform of instrument response (e.g. pH, Beer-Lambert law). This assumption ignores commonly encountered second and third order effects that may result in significant departures from the simple linear model and induce significant bias in test results. Examples of higher order effects and calibration algorithms that provide workable solutions will be discussed.

Specific topics covered:

  • Evaluation of calibration algorithms during method validation: goodness of fit, linearity.
  • Why the correlation coefficient should not be used for assessing "goodness of fit, or acceptability of a calibration".
  • Residuals: what they are, the important information contained in residuals plots, why they should be used routinely in assessing calibration curves.
  • Handling outliers in calibration curves.
  • Dangerous software features such as "slope update", & "force zero".

 

Edgar Paski
Ph.D.
Consulting Chemist

Edgar as both a B.Sc. Chemistry from the University of Waterloo as well as a Ph.D. Analytical Chemistry from the University of British Columbia.

He has served as a(n):
* Instructor, British Columbia Institute of Technology part time studies program
* Assessor for ISO 17025 for several accreditation bodies
* Trainer for Agilent Technologies Inc.
* Consultant to organizations in South-east Asia, Middle-east, North and South America

His interests include: Laboratory quality management, analytical atomic spectrometry, luminescence spectrometry, sampling for chemical analysis, speciation of inorganic substances, assaying of precious metals, rock and mineral analysis, chemometrics, environmental analytical chemistry, chemical metrology, pulp and paper, industrial products, petroleum.


Analytical Issues Related to Selenium In The Context Of The Revised Metal Mining Effluent Regulations (Regulatory Stream)

Environment Canada is currently in the process of revising the national Metal Mining Effluent Regulations, and is in consultation with relevant stakeholders on these revisions. Selenium is a metalloid chemical of concern being monitored in the effluents of various mining operations. This presentation will focus on a discussion of various analytical issues pertaining to industrial reporting for regulatory purposes. Specifically, the importance of practical quantitation limits (PQLs) and method detection limits (MDLs), in the context of applying regulatory guidelines and effluent discharge limits, will be evaluated and discussed.

 

James Downie
Owner
JRD Consulting & Borealis Environmental


Effective Quality Management Of Weighing Instruments (Quality Management Stream)

One of the key factors for traceable weighing results is effective calibration and routine testing embedded in the quality management system of an organization. While calibration of weighing instruments is well understood on a metrology level, there are still many ambiguities within the quality department, the laboratory or the shop floor on how to interpret calibration data and proof the validity of weighing results. Especially the concept of minimum weight which is a direct consequence of measurement uncertainty is not established well in the industry despite of the existence of specific balance regulations as e.g. USP General Chapter 41 "Balances".

This session introduces GWP, the global standard for risk-based lifecycle management of weighing equipment. It provides scientific guidance regarding calibration and routine operation of the instruments. GWP takes into consideration the following standards:

  • First, metrological guidelines such as OIML R76-1 and NIST HB44 set the minimum requirements for an approved weighing device. As their purpose is setting a legal framework to commercial transactions, they lack reference to individual user and process requirements.
  • Second, quality standards like ISO/IEC, GMP, GLP, USP and others require periodic equipment monitoring. Because of its generic scope, however, the standards do not provide any concrete information on its implementation.

GWP provides scientific knowledge about the specific methodology and the frequencies of regular calibration and routine tests required by quality standards, based on the respective process accuracy requirements and the risk of the weighing application. The concept of minimum weight ensures that all measurements come with a controlled measurement uncertainty, meeting the specific accuracy requirements. The risk-based approach, on the other hand, provides a systematic methodology to define calibration and test frequencies. Specifically regarding routine testing there are widespread misconceptions throughout the industries. Proven by experimental data, a scientific strategy is presented that defines appropriate testing to qualify weighing equipment in a cost-effective and efficient manner. What you will take away:

  • Understand the science behind calibration and testing of weighing instruments
  • Establish and proof the qualified range of weighing instruments based on measurement uncertainty and minimum weight
  • Learn how to use a risk-based approach to define suitable test intervals

Martin Huber
Head
Good Weighing Practice Competence Center
Metter Toledo

Martin has been with METTLER TOLEDO since 2003. He is responsible for GWP – The Weighing Standard, and consults the industry to achieve quality assurance and regulatory compliance of their various weighing processes.

Martin holds a Ph.D. in Chemistry of the Swiss Federal Institute of Technology (ETH). Prior to joining METTLER TOLEDO, Martin worked in the chemical and pharmaceutical industry, starting his career as plant manager of active pharmaceutical ingredients at Roche, Switzerland.

12:00 pm - 1:00 pm
Lunch (Trade Show Area)
1:00 pm - 2:00 pm
Redefining "High Resolution ICP-MS" For The Elemental Analysis Of Environmental Samples (Agilent) (Technologies Stream)

The determination of trace elements As, Se, Cd and Hg by ICP-MS is hampered by spectral interferences. Notably, the overlap from 40Ar35Cl+ and 40Ca35Cl+ on 75As+, 40Ar38Ar+ and 40Ca38Ar+ on 78Se+, 95Mo16O+ and 94Mo16OH+ on 111Cd+, and 184W16OH+ on 111Hg+ are so severe that a high mass resolution of 8,000 to 30,000 is required to resolve all these interferences. If the interfering peak is greater than the analyte peak, a much greater resolution is required. The more contaminated the sample, the worse the interference and more severe the degradation in accuracy and detection capability. At a mass resolution >8,000, over 95% of the analytical signal is lost in conventional sector field systems. Mathematical corrections for such interferences are painstaking, inaccurate, and fraught with uncertainties.

Agilent's latest ICP-MS technology can easily and reliably resolve these interferences, with good sensitivity and detection limits for matrices laden in interferences occurring at different concentrations and proportions. The basic principles of spectral interference control using chemical resolution, mass resolution, relaxation focusing and kinetic energy discrimination will be explained.

Pamela Wee
Product Specialist
Agilent Technologies

ICP-MS, ICP-MS/MS Product Specialist


Development Of A New Method For The Determination Of Mercury In Aqueous Samples (Technologies Stream)

The Laboratory Service Branch (LaSB) of the Ministry of the Environment analyzes several hundred water samples for mercury every year in support of the Ministry's various Regulatory and Monitoring Programs. Recently, LaSB had purchased two new instruments capable of analyzing mercury in aqueous levels lower than previously possible with our current instrumentation. The presentation will discuss the process of developing, comparing and validating the new analytical method.

Peter Drouin
Senior Laboratory Scientist
Ontario Ministry of the Environment

Peter Drouin is a scientist in the Spectroscopy and Physical Chemistry Section of the Ontario Ministry of the Environment's Laboratory Service Branch


The CALA Current Sampling Practices Guide (Quality Management Stream)

Sampling is typically required for both monitoring and for research purposes. Sampling data may be used to monitor air and water effluents or to characterize various environmental media (air, water, soil, biota) for pollutant levels. It may also be used to comply with regulatory requirements, detect accidental releases, identify trends, or develop an inventory or database of pollutant levels.

The CALA Current Sampling Practices Guide has been developed to provide anyone involved in environmental or many other types of sampling with sufficient information in the form of existing best practice examples, to plan and carry out scientifically defensible sample collection for submission to a laboratory for analysis.

The intent is to show what documentation is currently available on the subject of what happens between the time that a sampler (an individual who does sampling) receives instructions to visit a sampling target and when the sample arrives at the laboratory for testing.

The intent is not to recommend or mandate particular sampling instructions, rather to show what the body of knowledge on the subject is currently.

With this Guide we hope that users of the information can identify areas where:

  • There is lots of useful information available for people to use
  • There is a lack of useful information
  • Where that information might conflict between jurisdictions.

Peter Fowlie
Director
Cornerstone Science

Peter Fowlie is Director of Cornerstone Science, specializing in quality management of scientific activities. With over 25 years experience in laboratory operations, he is the former laboratory manager of the Wastewater Technology Centre and is actively involved in all facets of laboratory QA/QC. Several of the laboratories Peter has worked with are now accredited to ISO / IEC Standard 17025.

Peter is a consultant in analytical chemistry, a technical trainer and technical manager with proven problem solving skills. Particular strengths are in communicating and explaining technical issues to non-technical audiences.

Peter is expert in analytical chemistry, environmental chemistry, radiochemistry and quality management, training programs, leading technical groups and resolving conflicts between groups.

Peter provides training courses in Uncertainty in Sampling and Compliance Assessment, Measurement Uncertainty for Chemistry Laboratories, Method Validation for Chemistry Laboratories, Statistical tools for Laboratories and Scientific Management for Laboratories.

2:00 pm - 3:00 pm
Door Prize Draws & Closing Remarks 25 Year Anniversary-Retrospective on CALA